Catalysis Science & Engineering, Sponsor talk
CE-021

Process Related Aspects of Industrial Fluorine Chemistry 

C. Täschler1
1Lonza Ltd, Lonzastrasse, 3930-Visp, Switzerland -

Numerous active ingredients in the pharmaceutical and agro chemical industry as well as material sciences[1] contain fluorine as a crucial part, determining the desired properties of the ingredient to a large extent[2]

The production of fluorine containing ingredients on an industrial scale, however, poses several challenges addressing reactivity, toxicity, material of construction and more. The combination of these challenges with increasingly complex actives as well as the expectations for fast and cost efficient launch of new products forces one to use efficient ways to make these products. 
Some aspects of such new ways may not only involve the use of typical modern industrial concepts but also require new chemical methods such as catalytical fluoroalkylations avoiding the use of costly and waste intensive reagents. 

[1] G. Siegemund, W. Schwertfeger, A. Feiring, B. Smart, F. Behr, H. Vogel, B. McKusick, P. Kirsch, in Ullmann's Encyclopedia of Industrial Chemistry, 2016
[2] H. Groult, F. Leroux, A. Tressaud, Modern Synthesis Processes and Reactivity of Fluorinated Compounds, Elsevier, 2016